2025-06-24 06:32 |
Preclinical investigation of [$^{149}$Tb]Tb-DOTATATE and [$^{149}$Tb]Tb-DOTA-LM3 for tumor-targeted alpha therapy
/ Mapanao, Ana Katrina (PSI, Villigen) ; Busslinger, Sarah D (PSI, Villigen) ; Mehta, Avni (PSI, Villigen) ; Kegler, Kristel (Unlisted, CH) ; Favaretto, Chiara (PSI, Villigen ; Unlisted, CH) ; Grundler, Pascal V (PSI, Villigen) ; Talip, Zeynep (PSI, Villigen) ; Köster, Ulli (Laue-Langevin Inst.) ; Johnston, Karl (CERN) ; Schibli, Roger (PSI, Villigen ; Zurich, ETH) et al.
Terbium-149 is a short-lived α-particle emitter, potentially useful for tumor-targeted therapy. The aim of this study was to investigate terbium-149 in combination with the somatostatin receptor (SSTR) agonist DOTATATE and the SSTR antagonist DOTA-LM3. [...]
2025 - 16 p.
- Published in : European Journal of Nuclear Medicine and Molecular Imaging 52 (2025) 1383-1398
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2025-03-27 06:11 |
Production and purification of molecular $^{225}$Ac at CERN-ISOLDE
/ Au, M (CERN ; U. Mainz, PRISMA) ; Nies, L (CERN ; Greifswald U.) ; Stegemann, S (CERN) ; Athanasakis-Kaklamanakis, M (CERN ; Leuven U. ; Imperial Coll., London) ; Cocolios, T E (CERN ; Leuven U.) ; Fischer, P (Greifswald U.) ; Giesel, P F (Greifswald U.) ; Johnson, J D (Leuven U.) ; Köster, U (CERN ; Laue-Langevin Inst.) ; Lange, D (Heidelberg, Max Planck Inst.) et al.
The radioactive nuclide $^{225}$Ac is one of the few promising candidates for cancer treatment by targeted-$\alpha$-therapy, but worldwide production of $^{225}$Ac faces significant limitations. In this work, the Isotope Separation On-Line method was used to produce actinium by irradiating targets made of uranium carbide and thorium carbide with 1.4-GeV protons. [...]
2024 - 13 p.
- Published in : J. Radioanal. Nucl. Chem. 334 (2025) 367-379
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2024-10-09 15:03 |
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Fully upgraded $\beta$-NMR setup at ISOLDE for high-precision high-field studies
/ Jankowski, M. (CERN ; Darmstadt, Tech. U.) ; Azaryana, N. (Mickiewicz U., Poznan) ; Baranowski, M. (CERN ; Mickiewicz U., Poznan) ; Bissell, M.L. (CERN ; Manchester U.) ; Brand, H. (Darmstadt, GSI) ; Chojnacki, M. (CERN ; Geneva U.) ; Croese, J. (CERN ; Geneva U. ; TNO/TPD Space Instrum.) ; Dziubinska-Kühn, K.M. (CERN ; Leipzig U. ; Maastricht U.) ; Karg, B. (Geneva U.) ; Madurga Flores, M. (Tennessee U.) et al.
$\beta$-NMR is an advancing technique that enables measurements relevant to various fields of research, ranging from physics to chemistry and biology. [...]
arXiv:2410.00186.
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15.
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2024-08-23 16:08 |
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2024-08-02 09:02 |
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2024-07-18 04:21 |
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2024-07-18 04:20 |
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2024-07-04 06:31 |
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2024-06-12 04:48 |
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2024-06-11 06:40 |
Production study of Fr, Ra and Ac radioactive ion beams at ISOLDE, CERN
/ Jajčišinová, E (Geel, JRC ; Leuven U.) ; Dockx, K (Leuven U.) ; Au, M (CERN) ; Bara, S (Leuven U.) ; Cocolios, T E (Leuven U.) ; Chrysalidis, K (CERN) ; Farooq‑Smith, G J (Leuven U. ; Edinburgh U.) ; Fedorov, D V (Unlisted) ; Fedosseev, V N (CERN) ; Flanagan, K T (Manchester U.) et al.
The presented paper discusses the production of radioactive ion beams of francium, radium, and actinium from thick uranium carbide (UC$_{x}$) targets at ISOLDE, CERN. This study focuses on the release curves and extractable yields of francium, radium and actinium isotopes. [...]
2024 - 9 p.
- Published in : Sci. Rep. 14 (2024) 11033
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